In Denmark, a PNI is considered to be a high-risk feature requiring surgical removal with a resection margin of at least 6 mm, and in selected cases, Facial numbness sinus infection radiotherapy [ 16 ]. Acute sinusitis Acute sinusitis is most often caused by the common cold. It develops on sun-exposed sites, such as the head and neck, and is frequently treated with curettage [ 7 ]. Left-sided facial numbness is a common sign of MS. Skin cancer of the head and neck with clinical perineural invasion. Treating the underlying cause may help to alleviate Facial numbness sinus infection eliminate numbness. However, persistent sinusitis can lead to serious infections and other complications.