On the other hand, most Asians have an inactive variant of the second before-mentioned liver enzyme ALDH2. Population genetic studies on aldehyde dehydrogenase isozyme deficiency and alcohol sensitivity. Ask The Naked Scientists. Related Content Biology Chemistry. In the Asian metabolism etoh, the offending chemical, Disulfiramwas identified and by the Asian metabolism etoh it was marketed as the drug Antabuse. Genetic variability of enzymes of alcohol metabolism in human beings.